Research Categories - Infectious Disease
Study cellular processes in bacteria: protein folding, reduction and formation of protein disulfide bonds, membrane protein dynamics
Investigate fundamental molecular processes, including protein folding and disulfide bond formation, using E. coli as a model system
Bacterial Motility: Motor Response Based on Sensory Input
The Berg lab studies the motile behavior of bacteria in order to understand how cells sense and respond to changes in their environment. Processing external cues is a problem encountered by ...
NMR spectroscopy and membrane protein structure; viral ion channels; antiviral compounds
Apply advanced technologies to the reconstitution and structural biochemistry of membrane proteins, with a focus on viral ion channels; analyze the structure of membrane proteins at the level of ...
Real-time analysis of signal transduction and genetic networks at the single cell level
Investigating genome-wide transcriptional dynamics, and studying multi-drug resistance in bacteria.
Structural biology of retroviruses
The D’Souza laboratory investigates the structural basis of retroviral replication, including the initiation of reverse transcription and translation of viral genes. Understanding the ...
HIV and AIDS: vaccine; persistent immune response
Develop new strategies for blunting viral replication and bolstering the immune system’s ability to eradicate viral-infected T-cell reservoirs.
HIV infection and AIDS vaccine development
Investigate new approaches for AIDS vaccine development using SIV infection of non-human primates as a model system.
VIRAL ENTRY AND ANTI-VIRAL STRATEGIES Viral Receptors; HIV Therapy; Dengue Virus; SARS; Ebola Virus
Undertake translational studies geared toward the development of novel peptide mimetic inhibitors of HlV binding to its cell surface receptor, modeled after the CD4 and CCR5 HIV receptor/co-receptor; ...
Explores Identity and Territory in the Social World of Bacteria
Investigate the molecular mechanisms underlying the ability of bacterial cells to discriminate self from non-self; study the bacterium Proteus mirabilis, a Gram-negative opportunistic pathogen that ...
Virus structure, mechanism of entry into cells, and replication
Perform studies on poliovirus infection; investigate the proteomic composition of virus-laden membrane vesicles; study the herpes simplex virus replication complex and nuclear egress ...
Antiviral compound development (small molecule and biologicals)
- Antibiotic resistance»
- Bacillus subtilis»
- Escherichia coli (E. coli)»
- Gram-negative bacteria»
- Gram-positive bacteria»
- mar operon»
- Opportunistic pathogen»
- Proteus mirabilis»
- Staphylococcus aureus (S. aureus)»
- Viral structure»
- Virus entry»
Non-HIV Virus infections