Research Categories - Therapeutics

The range of studies that address therapeutics is expansive, encompassing biologic and cell-based therapies, small molecules, and diagnostics. Some examples include chimeric proteins for improving targeted therapy, stem cells for treating neurodegenerative diseases, radiolabeled prodrugs designed to offload cytotoxic activity only at the sites of tumors, and novel natural products having antibiotic properties.

Related Investigators

  1. Jon Clardy, PhD

    Isolation and characterization of small molecule natural products; high-throughput screening for novel therapeutics

    Discovering small molecule, natural products and their biology; high throughput screening for small molecule chemicals that interfere with microbial and mammalian cell processes.  

  2. Michael Farzan, PhD

    VIRAL ENTRY AND ANTI-VIRAL STRATEGIES Viral Receptors; HIV Therapy; Dengue Virus; SARS; Ebola Virus

    Undertake translational studies geared toward the development of novel peptide mimetic inhibitors of HlV binding to its cell surface receptor, modeled after the CD4 and CCR5 HIV receptor/co-receptor; ...

  3. Jose Halperin, MD

    Targeting protein translation for anticancer therapies; CD59 and diabetes

    Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes

  4. Robert Paul Johnson, MD

    HIV mechanism of action and new AIDS therapies

    Gene therapy; vaccines

  5. Amitinder Kaur, MD

    AIDS pathogenesis and CMV opportunistic infection: SIV; vaccine; AIDS resistance

    AIDS modeling in non-human primates; reactivation of latent CMV in HIV-infected individuals; innate resistance to SIV-related disease progression.  

  6. Roberto Kolter, PhD

    Microbial physiology

    Explore gene expression, community behavior, and biochemical aspects of bacterial biofilms; investigate microbial genomics.  

  7. Galit Lahav, PhD

    The p53 tumor suppressor as a model for studying temporal dynamics of signaling networks

    Investigate protein dynamics at the single cell level; quantification of proteins in live cells using fluorescence microscopy and mathematical modeling; cellular decision-making in cancer and healthy ...

  8. David Sinclair, PhD

    Sirtuins in aging and disease: calorie restriction; mitochondria; cancer; diabetes

    Study sirtuin pathways, their role in multiple diseases and their lifespan extension capabilities.

  9. Roger Spealman, PhD

    CNS disorders: addiction; Parkinson’s disease

    Studies on the mechanisms and efficacy of psychoactive drugs  

  10. Michael Starnbach, PhD

    Bacterial infection and acquired immunity

    T-cell response to bacterial infection, including sexually transmitted chlamydia disease