Research Categories - Therapeutic Discovery Tools and Assays

Innovative DNA sequencing procedures, high throughput screening assays for genetic studies and small molecule inhibitors, and computational analysis of signaling pathways are just some of the methodologies that are being employed for diagnostic and therapeutic discovery purposes.

Related Investigators

  1. Azad Bonni, MD, PhD

    Neuronal cell development; glioblastoma

    Investigate key intracellular signaling pathways in neuronal cell development and maturation as well as in brain tumors such as glioblastoma  

  2. George Church, PhD

    Personal Genome Project

    Genomic DNA Sequencing Technologies; Gene Synthesis; Biofuel

  3. Walter Fontana, PhD

    Information biology: principles, limits, and evolution of information processing in molecular systems

    Develop, apply, and establish the concept of programs as models to represent, model, and analyze complex systems of molecular interactions underlying cellular behavior; empirically characterize and ...

  4. Norbert Perrimon, PhD

    Modeling developmental processes and signaling pathways in Drosophila

    Use Drosophila as a model organism to explore basic biological mechanisms of development and cellular signaling, with a focus on muscle physiology.

  5. Samara Reck-Peterson, PhD

    Intracellular cargo movement: the role of molecular motors

    Explore the role of dynein in molecular cargo transport

  6. Arlene Sharpe, MD, PhD

    T-cell regulation and disease: chronic viral infection; autoimmunity, tumor immunotherapy, peripheral tolerance

    T cell co-stimulation and its immunoregulatory role in controlling the balance between T cell activation and tolerance.  

  7. Roger Spealman, PhD

    CNS disorders: addiction; Parkinson’s disease

    Studies on the mechanisms and efficacy of psychoactive drugs  

  8. Michael Starnbach, PhD

    Bacterial infection and acquired immunity

    T-cell response to bacterial infection, including sexually transmitted chlamydia disease

  9. Kevin Struhl, PhD

    Eukaryotic Transcriptional Regulation

    Investigate basic mechanisms of gene regulation in yeast; Employ mammalian cell models of tumorigenesis to elucidate genetic changes that underlie cancer development and progression  

  10. Fred Winston, PhD

    Mechanisms of eukaryotic gene expression in yeast: transcriptional regulation; chromatin structure

    Employs yeast as a model organism to study mechanisms of eukaryotic transcriptional regulation.