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Displaying: 1 - 10 of 17 Results
Sunlight-induced catalysis for biofuel and electricity generation
A new graphene-based material architecture for facilitating catalysis has been developed in the lab of Professor Lene Hau. The hybrid biological and nano-engineered structure acts as an artificial cell-membrane to control electron and proton…
Investigators
- Lene Hau
Promising new hand disinfection technology to eliminate pathogens
Pathogens found in the air and on surfaces present a massive global health challenge, threating human health and food security. With the increased prevalence of antibiotic-resistant bacteria and the use of harmful chemicals in typical…
Investigators
- Philip Demokritou
- Georgios Pyrgiotakis
- Joseph Brain
- Nachiket Vaze
- Mary Eleftheriadou
Novel annulation catalysts via direct C-H bond amination
Introducing functionality into unactivated C-H bonds, a ubiquitous group in organic molecules, remains a significant challenge due to the inertness of the substrate. Traditional synthesis strategies involve functional group exchange, an inefficient…
Investigators
- Theodore Betley
- Elisabeth Hennessy
- Alexandre Mikhailine
- Claudia Kleinlein
- Yuyang Dong
- Yunjung Baek
Continuous directed evolution of aminoacyl-tRNA synthetases to alter amino acid specificity and enhance activity
DESCRIPTION Functions of various biotherapeutics can often be enhanced by modifying individual amino acid residues. However, the current approaches rely on existing natural amino acid chemistry. Approaches that provide new chemical “handles” will…
Investigators
- David Liu
Studying interactions between essential bacterial ABC (ATP-binding cassette) transporter MsbA and bacterial LPS to pave the way for new antibiotic discovery
Gram-negative bacteria cause multiple infectious disease and are increasingly becoming resistant to antibiotics. However, development of drugs targeting these organisms is complicated by the extreme complexity of the structure of gram-negative cell…
Investigators
- Maofu Liao
Intracellular delivery of proteins: Aurin 1.2, an efficient non-endosomal protein delivery platform
To fully realize the therapeutic potential of proteins, exogenous proteins need to access intracellular targets. Since the vast majority of proteins cannot spontaneously cross cell membranes, a range of delivery platforms have been developed. These…
Investigators
- David Liu
First in class substrate-selective Insulin Degrading Enzyme (IDE) inhibitors for treating Diabetes
First in class substrate-selective Insulin Degrading Enzyme (IDE) inhibitors for treating Diabetes. Professor David Liu and a multidisciplinary research team have recently discovered and optimized of a series of small molecules (<550 Da, IC50 = 1…
Investigators
- David Liu
- Juan Pablo Maianti
Highly specific chemical detection using NMR at low magnetic fields
NMR often does not have sufficient resolution to distinguish between chemicals with related or similar structures in the presence of a large background, which leads to poor chemical specificity. The NMR spectra of complex chemical mixtures may…
Investigators
- Ronald Walsworth
- Matthew Rosen
- Stephen DeVience
Phaeobacticides - Potent and selective new class of algae growth inhibitors
Algae are a diverse group of uni- and multicellular plants that grow in water. Undesired and uncontrolled algal blooms are a recurring problem in bodies of water such as swimming pools, aquaculture ponds, aquariums, industrial drainage systems and…
Investigators
- Jon Clardy
- Roberto Kolter
- Mohammad Seyedsayamdost
- Rebecca Case
Oxygen-activated gold as a green catalyst for selective methoxycarbonylation
A group of Harvard scientists led by Profs. Madix and Friend has developed a catalyst based on gold for very selective production of dimethyl carbonate. The new process is environmentally friendly and its advantages are threefold. First, it starts…
Investigators
- Cynthia Friend
- Robert Madix
- Bingjun Xu