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Small Molecule Therapeutics
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Displaying: 1 - 10 of 18 Results
Preventing Stress-Induced Greying of Hair
Loss of hair pigmentation has long been associated with stress; however, stress-related changes at the level of the somatic cell have only recently been elucidated. The hair follicle consists of two stem cell populations: epithelial-derived hair…
Investigators
- Ya-Chieh Hsu
- Bing Zhang
Inhibiting Microbial Metabolism of Levodopa to Increase Availability in the CNS
Parkinson’s disease (PD) impacts 10 million people globally, with 60,000 Americans newly diagnosed every year. Levodopa remains the gold standard treatment for PD, despite limitations including side effects and peripheral metabolism. Current…
Investigators
- Emily Balskus
Compounds that block human cytomegalovirus by targeting the nuclear egress complex
Researchers in Dr. Donald Coen’s lab have identified molecules that inhibit human cytomegalovirus (HCMV) virion egress from the cell, effectively inhibiting HCMV replication. The team is looking to expand on these findings in collaborations that…
Investigators
- Donald Coen
Novel annulation catalysts via direct C-H bond amination
Introducing functionality into unactivated C-H bonds, a ubiquitous group in organic molecules, remains a significant challenge due to the inertness of the substrate. Traditional synthesis strategies involve functional group exchange, an inefficient…
Investigators
- Theodore Betley
- Elisabeth Hennessy
- Alexandre Mikhailine
- Claudia Kleinlein
- Yuyang Dong
- Yunjung Baek
Polymixin synergistic novobiocin analogs for efficacious and safer treatment of Gram negative infections
The lipopolysaccharide (LPS) containing outer membrane of Gram-negative bacteria prevent penetration of antibiotics, making them ineffective against infections. Polymyxins, including colistin, bind LPS and disrupt the outer membrane and hence are…
Investigators
- Daniel Kahne
Stapled peptide that inhibits bacterial transporter
Multidrug-resistant infection has become a worldwide epidemic in recent years especially in hospitals and other community-associated settings, causing great suffering of patients and huge healthcare burden. According to CDC, at least 23,000 people…
Investigators
- Martin Karplus
Novel antibiotics against Gram-negative and drug-resistant bacterial pathogens
Dr. Kahne has a pipeline of programs aimed at developing first-in-class antibiotics:Program I: Potentiator of polymixin, increasing its therapeutic index for treatment of drug-resistant infectionsIn vitro: Novel agent potentiates activity of…
Investigators
- Daniel Kahne
SIM-PAL: proteome wide identification of small molecule binding sites
Precise target identification for small molecules is an important and essential step in drug development. Despite its importance, there are very few unbiased, proteome-wide approaches aimed at identifying binding partners for small molecules. In…
Investigators
- Christina Woo
Small molecule inhibitors of Zika, dengue and other flaviviruses
Currently, broadly-protective antivirals targeting flaviviruses such as Zika, Dengue and West Nile viruses, are not available. Researchers in the laboratory of Dr. Priscilla Yang have identified a group of small molecules, including a prototype…
Investigators
- Priscilla Yang
Targeting spiral ganglion neurons for treatment of hearing loss
Hearing loss makes interactions with the world challenging for over 30 million people in the United States. While cochlear implants and hearing aid devices can ameliorate hearing loss, they often fail to restore the function of spiral ganglion…
Investigators
- Lisa Goodrich